Development of a technique to detect the activated form of the progesterone receptor and correlation with clinical and histopathological characteristics of endometrioid adenocarcinoma of the uterine corpus.
Identifieur interne : 002F34 ( Main/Exploration ); précédent : 002F33; suivant : 002F35Development of a technique to detect the activated form of the progesterone receptor and correlation with clinical and histopathological characteristics of endometrioid adenocarcinoma of the uterine corpus.
Auteurs : Jacques Bonneterre [France] ; Emilie Hutt [France] ; Jacques Bosq [France] ; J Dinny Graham [Australie] ; Matthew A. Powell [États-Unis] ; Eric Leblanc [France] ; Keiichi Fujiwara [Japon] ; Thomas J. Herzog [États-Unis] ; Robert L. Coleman [États-Unis] ; Christine L. Clarke [Australie] ; Erard M. Gilles [États-Unis] ; Alexander A. Zukiwski [États-Unis] ; Bradley J. Monk [États-Unis]Source :
- Gynecologic oncology [ 1095-6859 ] ; 2015.
Descripteurs français
- KwdFr :
- Antigène KI-67 (analyse), Antigène KI-67 (métabolisme), Carcinome endométrioïde (), Carcinome endométrioïde (anatomopathologie), Carcinome endométrioïde (métabolisme), Femelle, Fixation tissulaire, Formaldéhyde, Grading des tumeurs, Humains, Immunohistochimie, Inclusion en paraffine, Pronostic, Récepteur alpha des oestrogènes (analyse), Récepteur alpha des oestrogènes (métabolisme), Récepteurs à la progestérone (analyse), Récepteurs à la progestérone (métabolisme), Stade de la tumeur, Tumeurs de l'endomètre (), Tumeurs de l'endomètre (anatomopathologie), Tumeurs de l'endomètre (métabolisme).
- MESH :
- analyse : Antigène KI-67, Récepteur alpha des oestrogènes, Récepteurs à la progestérone.
- anatomopathologie : Carcinome endométrioïde, Tumeurs de l'endomètre.
- métabolisme : Antigène KI-67, Carcinome endométrioïde, Récepteur alpha des oestrogènes, Récepteurs à la progestérone, Tumeurs de l'endomètre.
- Carcinome endométrioïde, Femelle, Fixation tissulaire, Formaldéhyde, Grading des tumeurs, Humains, Immunohistochimie, Inclusion en paraffine, Pronostic, Stade de la tumeur, Tumeurs de l'endomètre.
English descriptors
- KwdEn :
- Carcinoma, Endometrioid (chemistry), Carcinoma, Endometrioid (metabolism), Carcinoma, Endometrioid (pathology), Endometrial Neoplasms (chemistry), Endometrial Neoplasms (metabolism), Endometrial Neoplasms (pathology), Estrogen Receptor alpha (analysis), Estrogen Receptor alpha (metabolism), Female, Formaldehyde, Humans, Immunohistochemistry, Ki-67 Antigen (analysis), Ki-67 Antigen (metabolism), Neoplasm Grading, Neoplasm Staging, Paraffin Embedding, Prognosis, Receptors, Progesterone (analysis), Receptors, Progesterone (metabolism), Tissue Fixation.
- MESH :
- chemical , analysis : Estrogen Receptor alpha, Ki-67 Antigen, Receptors, Progesterone.
- chemistry : Carcinoma, Endometrioid, Endometrial Neoplasms.
- metabolism : Carcinoma, Endometrioid, Endometrial Neoplasms, Estrogen Receptor alpha, Ki-67 Antigen, Receptors, Progesterone.
- pathology : Carcinoma, Endometrioid, Endometrial Neoplasms.
- Female, Formaldehyde, Humans, Immunohistochemistry, Neoplasm Grading, Neoplasm Staging, Paraffin Embedding, Prognosis, Tissue Fixation.
Abstract
Hormonal therapy is generally reserved for patients with endometrial cancers that fail cytotoxic chemotherapy, but there is a lack of sufficiently sensitive diagnostics to identify potential responders. We sought to develop a diagnostic technique to detect activated progesterone receptors (APR) in endometrial cancers using routine immunohistochemistry (IHC) and to correlate the presence of APR with other histopathological features and clinical disease stage.
DOI: 10.1016/j.ygyno.2015.06.037
PubMed: 26142884
Affiliations:
- Australie, France, Japon, États-Unis
- Arizona, Missouri (État), New Jersey, Nouvelle-Galles du Sud, Ohio, Texas
- Saint-Louis (Missouri), Sydney
- Université de Sydney, École de médecine (Université Washington de Saint-Louis)
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002A17
- to stream PubMed, to step Curation: 002947
- to stream PubMed, to step Checkpoint: 002947
- to stream Ncbi, to step Merge: 002805
- to stream Ncbi, to step Curation: 002805
- to stream Ncbi, to step Checkpoint: 002805
- to stream Main, to step Merge: 002F35
- to stream Main, to step Curation: 002F34
Le document en format XML
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Electronic address: j-bonneterre@o-lambret.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Oscar-Lambret, 3 Rue Frédéric Combemale, 59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Hutt, Emilie" sort="Hutt, Emilie" uniqKey="Hutt E" first="Emilie" last="Hutt">Emilie Hutt</name><affiliation wicri:level="1"><nlm:affiliation>Centre Oscar-Lambret, 3 Rue Frédéric Combemale, 59000 Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Oscar-Lambret, 3 Rue Frédéric Combemale, 59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Bosq, Jacques" sort="Bosq, Jacques" uniqKey="Bosq J" first="Jacques" last="Bosq">Jacques Bosq</name><affiliation wicri:level="1"><nlm:affiliation>Institut Gustave Roussy, 114 Rue Édouard Vaillant, 94805 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Gustave Roussy, 114 Rue Édouard Vaillant, 94805 Villejuif</wicri:regionArea><wicri:noRegion>94805 Villejuif</wicri:noRegion><wicri:noRegion>94805 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Graham, J Dinny" sort="Graham, J Dinny" uniqKey="Graham J" first="J Dinny" last="Graham">J Dinny Graham</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Research, Westmead Millennium Institute Sydney Medical School - Westmead, University of Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Cancer Research, Westmead Millennium Institute Sydney Medical School - Westmead, University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Powell, Matthew A" sort="Powell, Matthew A" uniqKey="Powell M" first="Matthew A" last="Powell">Matthew A. Powell</name><affiliation wicri:level="4"><nlm:affiliation>Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Leblanc, Eric" sort="Leblanc, Eric" uniqKey="Leblanc E" first="Eric" last="Leblanc">Eric Leblanc</name><affiliation wicri:level="1"><nlm:affiliation>Centre Oscar-Lambret, 3 Rue Frédéric Combemale, 59000 Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Oscar-Lambret, 3 Rue Frédéric Combemale, 59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Fujiwara, Keiichi" sort="Fujiwara, Keiichi" uniqKey="Fujiwara K" first="Keiichi" last="Fujiwara">Keiichi Fujiwara</name><affiliation wicri:level="1"><nlm:affiliation>Saitama Medical University International Medical Center, Hidaka Campus, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Saitama Medical University International Medical Center, Hidaka Campus, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241</wicri:regionArea><wicri:noRegion>Saitama 350-1241</wicri:noRegion></affiliation></author><author><name sortKey="Herzog, Thomas J" sort="Herzog, Thomas J" uniqKey="Herzog T" first="Thomas J" last="Herzog">Thomas J. Herzog</name><affiliation wicri:level="2"><nlm:affiliation>University of Cincinnati Cancer Institute, 3255 Eden Ave. Suite 250, Cincinnati, OH 45267, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati Cancer Institute, 3255 Eden Ave. Suite 250, Cincinnati, OH 45267</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Coleman, Robert L" sort="Coleman, Robert L" uniqKey="Coleman R" first="Robert L" last="Coleman">Robert L. Coleman</name><affiliation wicri:level="2"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Clarke, Christine L" sort="Clarke, Christine L" uniqKey="Clarke C" first="Christine L" last="Clarke">Christine L. Clarke</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cancer Research, Westmead Millennium Institute Sydney Medical School - Westmead, University of Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Cancer Research, Westmead Millennium Institute Sydney Medical School - Westmead, University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Gilles, Erard M" sort="Gilles, Erard M" uniqKey="Gilles E" first="Erard M" last="Gilles">Erard M. Gilles</name><affiliation wicri:level="2"><nlm:affiliation>Invivis Pharmaceuticals, 547 Meadow Road, Bridgewater, NJ 08807, USA; Arno Therapeutics, 200 Route 31 Flemington, NJ 08822, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Invivis Pharmaceuticals, 547 Meadow Road, Bridgewater, NJ 08807, USA; Arno Therapeutics, 200 Route 31 Flemington, NJ 08822</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Zukiwski, Alexander A" sort="Zukiwski, Alexander A" uniqKey="Zukiwski A" first="Alexander A" last="Zukiwski">Alexander A. Zukiwski</name><affiliation wicri:level="2"><nlm:affiliation>Arno Therapeutics, 200 Route 31 Flemington, NJ 08822, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arno Therapeutics, 200 Route 31 Flemington, NJ 08822</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Monk, Bradley J" sort="Monk, Bradley J" uniqKey="Monk B" first="Bradley J" last="Monk">Bradley J. Monk</name><affiliation wicri:level="2"><nlm:affiliation>University of Arizona Cancer Center-Phoenix, Creighton University School of Medicine at St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Arizona Cancer Center-Phoenix, Creighton University School of Medicine at St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author></analytic><series><title level="j">Gynecologic oncology</title><idno type="eISSN">1095-6859</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carcinoma, Endometrioid (chemistry)</term><term>Carcinoma, Endometrioid (metabolism)</term><term>Carcinoma, Endometrioid (pathology)</term><term>Endometrial Neoplasms (chemistry)</term><term>Endometrial Neoplasms (metabolism)</term><term>Endometrial Neoplasms (pathology)</term><term>Estrogen Receptor alpha (analysis)</term><term>Estrogen Receptor alpha (metabolism)</term><term>Female</term><term>Formaldehyde</term><term>Humans</term><term>Immunohistochemistry</term><term>Ki-67 Antigen (analysis)</term><term>Ki-67 Antigen (metabolism)</term><term>Neoplasm Grading</term><term>Neoplasm Staging</term><term>Paraffin Embedding</term><term>Prognosis</term><term>Receptors, Progesterone (analysis)</term><term>Receptors, Progesterone (metabolism)</term><term>Tissue Fixation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigène KI-67 (analyse)</term><term>Antigène KI-67 (métabolisme)</term><term>Carcinome endométrioïde ()</term><term>Carcinome endométrioïde (anatomopathologie)</term><term>Carcinome endométrioïde (métabolisme)</term><term>Femelle</term><term>Fixation tissulaire</term><term>Formaldéhyde</term><term>Grading des tumeurs</term><term>Humains</term><term>Immunohistochimie</term><term>Inclusion en paraffine</term><term>Pronostic</term><term>Récepteur alpha des oestrogènes (analyse)</term><term>Récepteur alpha des oestrogènes (métabolisme)</term><term>Récepteurs à la progestérone (analyse)</term><term>Récepteurs à la progestérone (métabolisme)</term><term>Stade de la tumeur</term><term>Tumeurs de l'endomètre ()</term><term>Tumeurs de l'endomètre (anatomopathologie)</term><term>Tumeurs de l'endomètre (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Estrogen Receptor alpha</term><term>Ki-67 Antigen</term><term>Receptors, Progesterone</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigène KI-67</term><term>Récepteur alpha des oestrogènes</term><term>Récepteurs à la progestérone</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome endométrioïde</term><term>Tumeurs de l'endomètre</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Carcinoma, Endometrioid</term><term>Endometrial Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Carcinoma, Endometrioid</term><term>Endometrial Neoplasms</term><term>Estrogen Receptor alpha</term><term>Ki-67 Antigen</term><term>Receptors, Progesterone</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigène KI-67</term><term>Carcinome endométrioïde</term><term>Récepteur alpha des oestrogènes</term><term>Récepteurs à la progestérone</term><term>Tumeurs de l'endomètre</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Endometrioid</term><term>Endometrial Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Formaldehyde</term><term>Humans</term><term>Immunohistochemistry</term><term>Neoplasm Grading</term><term>Neoplasm Staging</term><term>Paraffin Embedding</term><term>Prognosis</term><term>Tissue Fixation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Carcinome endométrioïde</term><term>Femelle</term><term>Fixation tissulaire</term><term>Formaldéhyde</term><term>Grading des tumeurs</term><term>Humains</term><term>Immunohistochimie</term><term>Inclusion en paraffine</term><term>Pronostic</term><term>Stade de la tumeur</term><term>Tumeurs de l'endomètre</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hormonal therapy is generally reserved for patients with endometrial cancers that fail cytotoxic chemotherapy, but there is a lack of sufficiently sensitive diagnostics to identify potential responders. We sought to develop a diagnostic technique to detect activated progesterone receptors (APR) in endometrial cancers using routine immunohistochemistry (IHC) and to correlate the presence of APR with other histopathological features and clinical disease stage.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Japon</li><li>États-Unis</li></country><region><li>Arizona</li><li>Missouri (État)</li><li>New Jersey</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Texas</li></region><settlement><li>Saint-Louis (Missouri)</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Bonneterre, Jacques" sort="Bonneterre, Jacques" uniqKey="Bonneterre J" first="Jacques" last="Bonneterre">Jacques Bonneterre</name></noRegion><name sortKey="Bosq, Jacques" sort="Bosq, Jacques" uniqKey="Bosq J" first="Jacques" last="Bosq">Jacques Bosq</name><name sortKey="Hutt, Emilie" sort="Hutt, Emilie" uniqKey="Hutt E" first="Emilie" last="Hutt">Emilie Hutt</name><name sortKey="Leblanc, Eric" sort="Leblanc, Eric" uniqKey="Leblanc E" first="Eric" last="Leblanc">Eric Leblanc</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Graham, J Dinny" sort="Graham, J Dinny" uniqKey="Graham J" first="J Dinny" last="Graham">J Dinny Graham</name></region><name sortKey="Clarke, Christine L" sort="Clarke, Christine L" uniqKey="Clarke C" first="Christine L" last="Clarke">Christine L. Clarke</name></country><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Powell, Matthew A" sort="Powell, Matthew A" uniqKey="Powell M" first="Matthew A" last="Powell">Matthew A. Powell</name></region><name sortKey="Coleman, Robert L" sort="Coleman, Robert L" uniqKey="Coleman R" first="Robert L" last="Coleman">Robert L. Coleman</name><name sortKey="Gilles, Erard M" sort="Gilles, Erard M" uniqKey="Gilles E" first="Erard M" last="Gilles">Erard M. Gilles</name><name sortKey="Herzog, Thomas J" sort="Herzog, Thomas J" uniqKey="Herzog T" first="Thomas J" last="Herzog">Thomas J. Herzog</name><name sortKey="Monk, Bradley J" sort="Monk, Bradley J" uniqKey="Monk B" first="Bradley J" last="Monk">Bradley J. Monk</name><name sortKey="Zukiwski, Alexander A" sort="Zukiwski, Alexander A" uniqKey="Zukiwski A" first="Alexander A" last="Zukiwski">Alexander A. Zukiwski</name></country><country name="Japon"><noRegion><name sortKey="Fujiwara, Keiichi" sort="Fujiwara, Keiichi" uniqKey="Fujiwara K" first="Keiichi" last="Fujiwara">Keiichi Fujiwara</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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